Two of the most talked-about skin boosters in UK aesthetic practice right now are Profhilo and Seventy Hyal 2000. Both are non-crosslinked hyaluronic acid injectables. Both improve skin quality without adding volume. Both have strong patient demand. Yet they are not the same product, and choosing between them, or deciding whether to stock both, requires a clear understanding of what each one actually does in the skin. This guide gives you that comparison.
What is Profhilo
Composition and Technology
Profhilo is manufactured by IBSA Derma (Switzerland/Italy) using patented NAHYCO Hybrid Technology. This thermal process combines 32mg of high molecular weight HA (H-HA: 1100-1400 kDa) with 32mg of low molecular weight HA (L-HA: 80-100 kDa) in a 2ml pre-filled syringe, giving a total HA concentration of 64mg/2ml. No chemical crosslinking agents such as BDDE are used. The two HA chains form hydrogen bonds during a controlled heating and cooling process, creating a Hybrid Cooperative Complex (HCC).
The result is a product that is technically non-crosslinked but thermally stabilised. It spreads cohesively through tissue rather than staying fixed at the injection point. This is why the BAP (Bio Aesthetic Points) protocol works: five injection points per half-face allow the product to spread across the full facial dermis.
How Profhilo Works in the Skin
Profhilo does not fill or volumise. It bio-remodels. Once injected, it stimulates fibroblasts and keratinocytes to produce collagen types I, III, IV, and VII, as well as elastin. The HA itself remains active in the tissue for approximately 28 days post-injection. During this time, it triggers a sustained biostimulatory response. The full effect on skin firmness and quality becomes visible four to six weeks after the second session.
Clinical studies report 98.7% patient satisfaction and 100% improvement in tissue quality markers. A 2025 open-label study in female patients demonstrated statistically significant improvements in skin hydration, elasticity, and tolerability across the treatment course.
Treatment Protocol
Initial course: Two sessions, four weeks apart.
Maintenance: One session every four to six months to maintain results.
Injection technique: BAP protocol: five points per half-face for original Profhilo. Injected into the subdermal layer.
Longevity: 6 to 9 months after the initial course, depending on age, skin condition, and lifestyle.
What is Seventy Hyal 2000
Composition and Technology
Seventy Hyal 2000 is manufactured by Seventy BG and contains high molecular weight sodium hyaluronate (>2000 kDa) at a 1.5% concentration. Each box contains three 2ml pre-filled syringes, giving a total HA of 90mg per 6ml (30mg per 2ml syringe). Like Profhilo, it is produced by bacterial fermentation without any chemical modification. It is non-crosslinked.
The defining feature of Seventy Hyal is its exceptionally high molecular weight. At over 2000 kDa, it sits among the highest molecular weight HA products on the market. Profhilo’s H-HA is 1100-1400 kDa by comparison. This molecular size difference has practical implications for how the product behaves in tissue and how long it remains active.
How Seventy Hyal Works in the Skin
High molecular weight HA demonstrates stronger CD44 receptor binding, which triggers collagen and elastin production and exerts anti-inflammatory effects in the tissue. It also degrades more slowly than low molecular weight HA. Where low molecular weight HA products may remain active for only 7 to 10 days before macrophage clearance, Seventy Hyal’s high molecular weight means sustained biostimulatory activity for up to four weeks per session.
Seventy Hyal is designed primarily for deep skin hydration, improved elasticity, and skin glow. It does not provide the structural or tightening benefit that Profhilo’s dual H-HA and L-HA complex delivers. It is an excellent choice for patients seeking a hydration and radiance boost, particularly younger patients and those with dehydrated or dull skin.
Treatment Protocol
Initial course: 2 to 3 sessions, four weeks apart. A fourth session may be needed for more mature or compromised skin.
Maintenance: Every 4 to 6 months.
Injection technique: Linear threading or blanching technique. More flexible than Profhilo’s BAP protocol, allowing practitioners to customise placement.
Longevity: 6 to 12 months depending on skin condition and lifestyle.
Profhilo vs Seventy Hyal: Head-to-Head Clinical Comparison
| Factor | Profhilo | Seventy Hyal 2000 |
| HA Concentration | 64mg/2ml (32mg H-HA + 32mg L-HA) | 30mg/2ml (90mg per 6ml box) |
| Molecular Weight | H-HA: 1100-1400 kDa / L-HA: 80-100 kDa | > 2000 kDa |
| Crosslinked? | No (thermally stabilised) | No (no chemical modification) |
| Crosslinking Agent | None (BDDE-free) | None (BDDE-free) |
| Mechanism | Bio-remodelling: collagen types I, III, IV, VII + elastin stimulation | Biostimulation: collagen + elastin via CD44 receptor binding |
| Primary Action | Skin tightening, laxity, firmness, quality | Deep hydration, glow, radiance, skin texture |
| Sessions (Initial) | 2 sessions, 4 weeks apart | 2-3 sessions, 4 weeks apart |
| Maintenance | Every 4-6 months | Every 4-6 months |
| Longevity | 6-9 months | 6-12 months |
| Injection Technique | BAP Protocol (5 points per half-face) | Flexible: threading or blanching |
| Treatment Areas | Face, neck, decolletage, hands, arms | Face, neck, decolletage, hands, body |
| CE Marked? | Yes | Yes |
| Clinical Studies | Substantial: multiple peer-reviewed publications | Limited independent long-term data |
HA Concentration and Molecular Weight
Profhilo delivers 64mg of HA per 2ml syringe across two molecular weights. Seventy Hyal delivers 30mg per 2ml syringe at a single, very high molecular weight. In terms of raw HA volume, Profhilo is more than twice as concentrated per syringe. However, concentration alone does not determine clinical outcome. Molecular weight and mechanism of action matter equally.
Mechanism of Action
Profhilo’s dual molecular weight complex provides both immediate deep hydration (from L-HA) and sustained structural biostimulation (from H-HA). This two-pronged approach is what makes it effective for skin laxity and early tissue sagging. Seventy Hyal’s single high molecular weight HA delivers strong hydration and biostimulation through CD44 binding, but does not provide the same tightening or tissue-lifting effect that Profhilo’s H-HA and L-HA interaction achieves.
Treatment Areas
Both products treat the face, neck, decolletage, and hands. Seventy Hyal has broader body applications including stretch marks and skin laxity on the arms and abdomen. Profhilo’s spreadability via the BAP protocol makes it particularly well suited to the facial dermis, where controlled diffusion is a clinical advantage.
Number of Sessions and Spacing
Profhilo requires two sessions four weeks apart for the initial course. Seventy Hyal requires two to three sessions at the same spacing, with some patients needing a fourth. For your clinic, this means Seventy Hyal generates slightly more repeat bookings per initial treatment course, which affects both revenue and patient retention.
Longevity of Results
Profhilo results last 6 to 9 months. Seventy Hyal claims 6 to 12 months. The wider longevity window for Seventy Hyal is partly attributed to the extended tissue residence time of very high molecular weight HA. In practice, individual patient factors such as age, lifestyle, and skin condition will influence actual longevity for both products.
Cost to Clinic and Patient Pricing
Wholesale pricing varies. As a general guide for UK clinics in 2025/2026, Profhilo typically costs more per syringe than Seventy Hyal. However, Profhilo’s two-session initial protocol versus Seventy Hyal’s two to three sessions means the total product cost per patient treatment course is more comparable than the per-unit price suggests. Patient-facing prices in the UK typically range from £300 to £600 for a Profhilo course and £200 to £450 for a Seventy Hyal course, depending on location, clinic positioning, and number of sessions.
Check current wholesale pricing for both products at Skin On You: Shop Skin Boosters at Skin On You.
Which Patients Are Best Suited to Each Product
Profhilo is the stronger choice for:
- Patients aged 35 and over with visible skin laxity, crepiness, or loss of firmness
- Patients who want tightening and bioremodelling, not just hydration
- Patients with early jowling, neck laxity, or loss of skin elasticity
- Patients who have had volume-based filler work and want to improve overall skin quality
- Patients with mature, sun-damaged, or thin skin
Seventy Hyal 2000 is the stronger choice for:
- Patients aged 18 to 40 seeking hydration, glow, and skin texture improvement
- Patients with dehydrated, dull, or lacklustre skin without significant laxity
- Patients who are cost-conscious and want an accessible skin booster course
- Patients wanting body treatment areas such as stretch marks or body skin laxity
- Patients on a maintenance programme who do not yet need Profhilo’s bioremodelling depth
Clinical Evidence and Studies
Profhilo has substantially more independent peer-reviewed clinical data than Seventy Hyal. Published studies include:
- A 2025 open-label study demonstrating significant improvements in skin hydration, elasticity, and tolerability in female patients
- A PMC-published safety review across 40,000+ patients showing an excellent safety profile with rare serious adverse events
- Multiple studies confirming stimulation of collagen types I, III, IV, and VII and elastin
Seventy Hyal has CE marking and growing practitioner adoption, but independent long-term clinical data remains limited compared to Profhilo. This is worth noting in your clinical decision-making, particularly for more complex patient presentations. For the most current IBSA clinical data on Profhilo, visit the IBSA Derma official site.
Can You Combine Profhilo and Seventy Hyal
Yes. Some practitioners use both in a treatment plan, separating them by indication. Seventy Hyal is offered to younger patients as an entry-level skin booster and maintenance treatment. Profhilo is positioned for patients with more mature skin or those wanting the additional tightening and structural bioremodelling effect. The two products are not competing in the same clinical space when used this way. They complement different patient needs.
Do not inject both products at the same session without clinical justification. There is no evidence base for simultaneous injection, and the interaction between the two HA formulations in the same tissue is not documented.
Profhilo vs Seventy Hyal: Practitioner Verdict
Stock Profhilo if: your patient base skews over 35, presents with skin laxity, and you want a product with a robust clinical evidence base and established UK market presence.
Stock Seventy Hyal if: you have a younger or broader patient demographic, want a more accessible price point, or need a flexible injection technique for body and off-face applications.
Stock both if: you treat a wide age range and want to offer a full skin booster menu. Differentiate by indication at the consultation stage.
Shop Profhilo at Skin On You: skinonyou.com/product-category/skin-booster/profhilo-skin-booster/
Skin On You Pharmacy is a UK GPhC-registered pharmacy (Reg No. 9012676) supplying aesthetic practitioners, doctors, nurses, and skin clinics across the UK. Register and shop at skinonyou.com.
