Description
Clinical Description
Nucleofill Strong Plus is a polynucleotide-based biostimulatory injectable medical-aesthetic device by Promoitalia, classified among skin-rejuvenation/mesotherapy products. Its core mechanism relies on high-density, highly purified polynucleotides (PNS) — at a concentration of 25 mg/ml — which act to biologically stimulate the skin’s fibroblasts, enhancing the natural production of collagen and elastin, while improving hydration and extracellular matrix integrity.Nucleofill Strong Plus is designed for skin showing signs of aging, stress, or decreased elasticity — aiming at structural skin renewal rather than volumization.
Short Marketing Description
Nucleofill Strong Plus offers a professional-grade solution for aesthetic practitioners seeking to deeply regenerate, hydrate, and lift mature or aging skin. By delivering concentrated polynucleotides directly into the dermis, it supports long-term skin rejuvenation: improved elasticity, smoother texture, reduction in fine lines, and enhanced overall skin quality. Its biostimulatory action makes it ideal for clients who prefer subtle, natural-looking results over volumizing fillers.
What Nucleofill Strong Plus Is Similar To
Nucleofill Strong Plus can be compared with other polynucleotide-based or bio-stimulating skin boosters rather than traditional volume fillers. For example, Sunekos — another biorevitaliser — also uses polynucleotides or amino-acid blends (depending on version) to stimulate fibroblast activity, improve hydration, and enhance skin elasticity. Both target skin quality and structural regeneration, rather than adding volume as with hyaluronic-acid fillers.
Similarly, products like Profhilo offer skin-boosting benefits but rely on high-concentration hyaluronic acid (HA) rather than PNs; while Profhilo excels in broad hydration and subtle firmness, Nucleofill Strong Plus aims for deeper dermal bio-remodeling via collagen/elastin stimulation.
This comparison is provided for clinical orientation only and does not imply interchangeability.
Treatment Areas / Indications
According to distributor and product-information sources, treatment areas for Nucleofill Strong Plus include:
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Face
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Neck
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Décolletage (chest)
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Hands (for skin rejuvenation)
If more specific areas are needed, refer to official IFU — currently not publicly detailed.
Usage / Administration (IFU-Only Section)
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Injection depth: not provided by manufacturer (public documentation for Nucleofill Strong Plus does not include a full official IFU specifying dermal layer depth)
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Volume per point / injection site: not provided by manufacturer
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Needle gauge: generally supplied with 30 G ½″ (≈ 13 mm) sterile disposable needles, according to distributors.
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Frequency / Number of sessions: not provided by manufacturer — published sources do not include an official treatment schedule for Strong Plus.
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Professional-use disclaimer: This product is intended for use by qualified medical professionals only; not for home/self-administration.
Note: Some practitioner protocols circulated online suggest using injection techniques such as the “BAP” (Bio-Aesthetic Points) method, multi-point, or mesotherapy injections — but these are not part of the officially published manufacturer IFU and should be considered as experiential guidance, not regulatory instructions.
Ingredient List
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Polynucleotides (polynucleotide gel) — 25 mg/ml concentration of highly purified PN.
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Excipients and other formulation details: not provided by manufacturer (no public data on buffers, preservatives, pH, molecular weight distribution, or additional excipients).
Presentation & Longevity
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Packaging: 1 × 2 ml prefilled syringe per pack.
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Shelf-life / storage conditions: not publicly specified — verify on the product pack or with distributor/IFU.
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Treatment duration / longevity of effects: According to supplier claims, results develop gradually after a course of treatments; maintenance sessions “every few months” are often recommended to preserve skin regeneration.
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Duration range (in months): not provided by manufacturer — no formal published longevity data.
Safety Notes / Contraindications
Publicly available documentation does not include a full contraindication list. Based on standard practice and distributor caution, use is contraindicated in patients with:
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Known hypersensitivity to any component (e.g., polynucleotides or formulation excipients) — assumed.
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Active skin infection, inflammation, or lesions at the injection site — assumed.
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Use only under aseptic conditions by licensed medical professionals — as per distributor guidance.
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For other safety-related contraindications (pregnancy, immunosuppression, systemic disease, etc.), verify with manufacturer and local regulatory guidelines.
Regulatory Status
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The product is reported as CE-marked (within European Community).
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For UK: verify UKCA marking or local registration (as import/medical-device regulations may apply). Public documentation does not provide explicit UKCA status.
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No publicly verified FDA approval — product appears marketed within Europe.
FAQ
Q1: How does Nucleofill Strong Plus work on the skin?
A1: Nucleofill Strong Plus uses high-density polynucleotides that, once injected into the dermis, stimulate fibroblast activity, leading to increased synthesis of collagen and elastin, essential structural proteins. The polynucleotides also attract and bind water molecules, enhancing hydration and improving extracellular matrix support — resulting in smoother, firmer, more resilient skin.
Q2: When can results be seen, and how long do they last?
A2: According to supplier sources, visible improvements often begin after the first few sessions; full effect typically develops over a course of treatments, with maintenance injections recommended every few months to sustain results. Because there is no published long-term clinical study available in public domain for “Strong Plus,” precise duration (e.g., months of maintained effect) is “not provided by manufacturer.”
Q3: Is Nucleofill Strong Plus the same as a dermal filler?
A3: No. Unlike traditional dermal fillers — which primarily add volume (e.g., via hyaluronic acid) — Nucleofill Strong Plus is a biostimulatory treatment designed to regenerate the skin’s structure at a cellular level without volumizing. It aims to improve skin quality, elasticity, hydration, and skin matrix integrity rather than creating contour or volume.
Q4: What areas of the body can be treated with Nucleofill Strong Plus?
A4: According to distributor information, Nucleofill Strong Plus is indicated for the face, neck, décolletage, and hands — areas commonly affected by aging, volume loss, or skin laxity. As always, treatment should be determined by a qualified aesthetic professional following patient assessment.
Q5: Who is eligible to administer Nucleofill Strong Plus — and is it safe for self-use?
A5: Nucleofill Strong Plus is intended for administration by licensed medical professionals experienced in injectable aesthetic treatments. It is not designed for self-injection or home use. The supplied documentation emphasizes that use is restricted to trained practitioners.
