Description
Clinical Description
Nucleofill Soft Plus 1 x 2 ml (formerly referred to as Nucleofill Eyes in some markets) is a polynucleotide-based biostimulating injectable designed for the delicate periocular region. Developed by Promoitalia, the product contains highly purified polynucleotides suspended in a sterile gel carrier and is intended to support skin quality improvement through hydration, tissue biostimulation, and dermal revitalisation.
Polynucleotides possess hydrophilic properties that contribute to water retention within the extracellular matrix while supporting a favourable environment for fibroblast activity. Nucleofill Soft Plus is specifically positioned for use in thin, fragile skin around the eyes, where concerns may include superficial wrinkles, dark circles, loss of elasticity, and periocular skin ageing.
Unlike volumising dermal fillers, Nucleofill Soft Plus is generally categorised as a skin biostimulator and tissue-quality enhancer rather than a product intended primarily for structural volume restoration.
What Nucleofill Soft Plus Is Similar To
Nucleofill Soft Plus belongs to the growing category of polynucleotide-based regenerative injectables. It is frequently compared with products such as Nucleofill Medium and Plinest®, both of which utilise purified nucleic-acid derivatives to support tissue revitalisation and hydration.
Compared with Nucleofill Medium, Soft Plus is formulated specifically for delicate periocular tissues and is generally used in areas where thinner skin requires a gentler approach.[1] Nucleofill Medium may be selected for broader facial rejuvenation indications, whereas Soft Plus is commonly associated with under-eye and periocular protocols.
Unlike hyaluronic acid skin boosters such as Profhilo®, which rely primarily on stabilised hyaluronic acid, Nucleofill Soft Plus uses polynucleotides as its principal active component.Both categories aim to improve skin quality, although their biological mechanisms differ.
This comparison is provided for clinical orientation only and does not imply interchangeability.
Treatment Areas / Indications
Based on available manufacturer and distributor information, reported treatment areas include:
- Periocular region
- Under-eye area
- Tear trough region
- Fine lines around the eyes
- Dark circles
- Periorbital wrinkles
- Delicate periocular skin requiring revitalisation
Usage / Administration (IFU-Only Section)
Injection depth: Not provided by manufacturer in publicly accessible IFU documentation reviewed.
Volume per injection point: Not provided by manufacturer.
Needle gauge: Public product information indicates inclusion of 30G needles; official injection recommendations not provided by manufacturer.
Treatment frequency / sessions: Not provided by manufacturer in verified IFU documentation.
Professional-use statement: The product should be administered only by appropriately trained healthcare professionals in accordance with local regulations and aseptic practice requirements.
Some practitioners utilise serial treatment protocols for periocular rejuvenation; however, specific regimens are not included in the manufacturer’s publicly available IFU and therefore are not reproduced here.
Ingredient List
Active ingredients
- Highly purified polynucleotides (PN)
- Polynucleotide concentration reported as approximately 7.5 mg/ml in publicly available product specifications
Excipients
- Physiological saline solution (0.9% sodium chloride), where specified
Hyaluronic acid concentration: Not provided by manufacturer.
Lidocaine content: Not provided by manufacturer.
Presentation & Longevity
Presentation
- 1 × 2 ml prefilled sterile syringe
- Sterile needles included in selected market presentations
- Single-use medical-aesthetic product
Shelf life: Not provided by manufacturer in publicly accessible documentation reviewed.
Longevity of results: Not provided by manufacturer. Clinical outcomes and duration may vary according to patient characteristics, treatment protocol, and practitioner assessment.
Safety Notes / Contraindications
Publicly available documentation does not provide a complete contraindication list.
General precautions include:
- Do not use in patients with known hypersensitivity to any product component.
- Avoid use in areas with active infection, inflammation, or skin disease.
- Use only by qualified healthcare professionals.
- Patients who are pregnant, breastfeeding, or undergoing medical treatment should be assessed according to professional clinical judgement and manufacturer guidance.
Refer to the latest product packaging and official manufacturer documentation before use.
Regulatory Status
- Manufacturer: Promoitalia (Italy)
- CE-marked product reported by multiple authorised distributors within European markets.
- Regulatory classification may vary by jurisdiction.
Verify current regulatory status using the latest manufacturer documentation, product packaging, and applicable national regulations before purchase or clinical use.
FAQ
1. What is Nucleofill Soft Plus?
Nucleofill Soft Plus is a polynucleotide-based injectable developed for periocular skin revitalisation. The product contains purified polynucleotides that support hydration and tissue-quality improvement within the delicate eye area. It is generally positioned as a regenerative skin-quality treatment rather than a volumising filler.
2. What concerns is Nucleofill Eyes commonly used for?
Publicly available product information associates Nucleofill Soft Plus with the treatment of superficial periocular wrinkles, dark circles, delicate under-eye skin, and overall periocular rejuvenation. Individual treatment suitability should always be determined by a qualified practitioner following patient assessment.
3. Does Nucleofill Soft Plus contain hyaluronic acid?
Available manufacturer and distributor information identifies polynucleotides as the principal active ingredient. Public documentation reviewed does not specify a hyaluronic acid component. Users should consult the latest manufacturer documentation for complete composition details.
4. How is Nucleofill Soft Plus different from traditional dermal fillers?
Traditional dermal fillers are typically designed to provide structural support and volume restoration. Nucleofill Soft Plus focuses primarily on tissue biostimulation, hydration support, and skin-quality improvement through the biological activity of polynucleotides. The intended treatment goals may therefore differ from those of volumising fillers.
5. How long do results from Nucleofill Soft Plus last?
The manufacturer does not provide a universally applicable duration of effect in publicly available documentation reviewed for this description. Treatment outcomes depend on patient characteristics, treatment area, lifestyle factors, and practitioner protocol. Maintenance schedules vary among clinics and should be determined individually.
