Description
Clinical Description
Nucleofill 25, commonly marketed as Nucleofill Strong, is a high-concentration polynucleotide-based injectable medical device developed by Promoitalia Medical Aesthetics. Designed for advanced skin bio-restructuring and tissue regeneration, it contains highly purified polynucleotides at a concentration of 25 mg/ml (2.5%), making it the strongest formulation within the Nucleofill range.
The product functions through multiple biological mechanisms. Polynucleotides provide intensive hydration through water-binding activity, support fibroblast stimulation, promote extracellular matrix regeneration, and contribute antioxidant protection against free radical damage. These combined effects aim to improve skin elasticity, firmness, texture, and overall tissue quality.
Nucleofill Strong is generally indicated for mature skin, significant skin laxity, photoaged skin, and areas requiring enhanced regenerative support. It is frequently selected by practitioners seeking a more intensive polynucleotide treatment compared with lower-concentration formulations such as Nucleofill Medium.
What Nucleofill Strong Is Similar To
Nucleofill Strong belongs to the growing category of regenerative injectable treatments, alongside products such as Nucleofill Medium, Plenhyage XL Strong, and Profhilo®.
Compared with Nucleofill Medium, Nucleofill Strong contains a higher concentration of polynucleotides (25 mg/ml versus 20 mg/ml), providing greater viscosity and a stronger regenerative profile intended for patients with more advanced skin ageing concerns.
Profhilo®, by contrast, is based on stabilised hyaluronic acid and primarily focuses on hydration and tissue remodelling. While both products aim to improve skin quality, Nucleofill Strong relies on polynucleotide-mediated fibroblast activation and antioxidant activity rather than hyaluronic acid bio-remodelling.
Similarly, other polynucleotide products may share regenerative goals, but formulation concentration, molecular characteristics, and treatment indications differ between manufacturers.
This comparison is provided for clinical orientation only and does not imply interchangeability.
Treatment Areas / Indications
According to publicly available manufacturer and distributor information, Nucleofill Strong may be used in:
- Face
- Neck
- Décolletage
- Hands
- Abdomen
- Inner arms
- Thighs
- Areas affected by skin laxity
- Areas affected by photoageing
- Stretch marks
- Superficial scars
Treatment suitability should be determined by a qualified healthcare professional following clinical assessment.
Usage / Administration (IFU-Only Section)
Injection Depth
Deep dermis administration is referenced within publicly available manufacturer documentation.
Volume per Injection Site
Not provided by manufacturer.
Needle Gauge
Supplied with:
- 2 × 30G needles
- Approximate needle length 12–13 mm
Frequency / Number of Sessions
Not provided by manufacturer.
Some practitioners utilise multi-session treatment protocols and maintenance schedules; however, these approaches are not included in the manufacturer’s publicly available official IFU guidance.
Professional Use Statement
Nucleofill Strong should only be administered by appropriately trained healthcare professionals using aseptic injection techniques and according to applicable local regulations.
Ingredient List
Active Ingredient
- Polynucleotide gel 25 mg/ml (2.5%)
Product Characteristics
- High molecular weight polynucleotides
- Approximate molecular weight: 2,500 kDa
- pH: 6.8–7.2
- Sterile injectable formulation
Excipients
Not provided by manufacturer.
Hyaluronic Acid Concentration
Not applicable.
Lidocaine
No lidocaine reported in publicly available product documentation.
Presentation & Longevity
Packaging
Nucleofill Strong is supplied as:
- 1 × 1.5 ml sterile syringe
- 2 × 30G needles included
Shelf Life
Not provided by manufacturer.
Treatment Duration / Longevity
Longevity is not provided by manufacturer in publicly available documentation.
Clinical outcomes vary according to patient factors, treatment area, practitioner technique, and individual biological response.
Safety Notes / Contraindications
Publicly available documentation provides limited contraindication information. Standard precautions include:
- Do not use in patients with known hypersensitivity to any product component.
- Avoid treatment in areas with active infection, inflammation, or skin disease.
- Product safety during pregnancy and breastfeeding has not been established.
- Administration should only be performed by qualified healthcare professionals.
As with all injectable procedures, appropriate aseptic technique and patient assessment are essential.
Regulatory Status
- CE-marked medical device.
- Reported as a Class III medical device within European medical device classifications.
- Intended exclusively for professional medical use.
UKCA status: verify via current IFU or authorised distributor documentation.
FAQ
1. What is Nucleofill Strong?
Nucleofill Strong is a high-strength polynucleotide injectable developed for skin bio-restructuring and regenerative aesthetic treatments. It contains 25 mg/ml purified polynucleotides designed to support hydration, tissue quality, and fibroblast activity while helping improve overall skin condition.
2. How is Nucleofill Strong different from Nucleofill Medium?
The primary difference is concentration. Nucleofill Strong contains 25 mg/ml polynucleotides, while Nucleofill Medium contains 20 mg/ml. The higher concentration provides a stronger regenerative profile and is often selected for patients with more advanced signs of skin ageing or tissue laxity.
3. Does Nucleofill Strong contain hyaluronic acid?
No. Nucleofill Strong is a polynucleotide-based injectable and does not rely on hyaluronic acid as its primary active ingredient. Its mechanism focuses on bio-stimulation, hydration support, antioxidant activity, and extracellular matrix enhancement through purified polynucleotides.
4. How long do Nucleofill Strong results last?
The manufacturer does not specify an exact duration of effect in publicly available documentation. Longevity may vary depending on treatment protocol, patient characteristics, skin condition, and maintenance schedules determined by the treating practitioner.
5. Is Nucleofill Strong a dermal filler?
Nucleofill Strong is generally classified as a regenerative injectable skin booster rather than a volumising dermal filler. Its primary purpose is to improve tissue quality, hydration, elasticity, and skin condition rather than providing structural volume replacement.
