Description
Clinical Description
Rejuran S (1 × 1ml) is a professional injectable polynucleotide (PN) skin rejuvenation device designed for use in aesthetic medicine procedures. It belongs to the category of regenerative skin boosters, using purified polynucleotide technology derived from salmon DNA fragments to support improvements in skin quality and tissue condition.
Unlike traditional hyaluronic acid dermal fillers that primarily provide structural volume, Rejuran S works through a bioregenerative approach, where polynucleotide molecules are designed to support the skin’s natural repair environment and improve dermal characteristics.
Rejuran S is specifically formulated for areas requiring targeted skin improvement, including areas where practitioners seek enhanced skin texture, elasticity, and overall skin condition. The product contains polynucleotide (PN) as its key active component. The exact concentration, excipients, and complete formulation details should be confirmed through the official manufacturer documentation.
What Rejuran S Is Similar To
Rejuran S belongs to the polynucleotide skin booster category and can be compared with other regenerative injectable treatments such as Rejuran I and other PN-based products used in aesthetic medicine.
Rejuran S and Rejuran I share the same polynucleotide-based technology but are designed for different treatment focuses. Rejuran S is generally positioned for areas requiring more targeted skin improvement, while Rejuran I is commonly associated with delicate skin areas such as the periocular region.
Another comparable category is hyaluronic acid-based skin boosters such as Profhilo. While both approaches aim to improve skin quality, their mechanisms differ. Profhilo uses stabilised hyaluronic acid technology, whereas Rejuran S uses polynucleotide technology designed to support the skin regeneration environment.
These products have different compositions, indications, and clinical protocols.
Treatment Areas / Indications
Based on available product information, Rejuran S is intended for professional aesthetic applications involving targeted skin rejuvenation.
Reported treatment applications include:
- Areas requiring improvement in skin texture and quality
- Localised areas requiring regenerative skin support
- Facial skin rejuvenation procedures
The product is commonly associated with targeted treatment areas where thicker skin or specific skin concerns require a specialised PN formulation.
Specific approved indications and anatomical treatment areas should always be confirmed through the official manufacturer Instructions for Use (IFU).
Usage / Administration (IFU-Only Section)
Rejuran S should only be administered by qualified medical professionals trained in injectable aesthetic procedures.
Administration must follow the official manufacturer Instructions for Use.
Available information:
Treatment should be performed under appropriate aseptic conditions and according to professional medical-device standards.
Some practitioners describe specific injection patterns and treatment protocols for polynucleotide products; however, these methods are not considered official manufacturer guidance unless specifically stated within the Rejuran S IFU.
Ingredient List
Rejuran S contains polynucleotide (PN) as its primary active component.
Available formulation information:
- Polynucleotide (PN) – purified DNA-derived biopolymer used as the key active ingredient in the formulation.
The exact composition should be verified from the official product packaging and manufacturer documentation supplied with the device.
Presentation & Longevity
Presentation
Rejuran S is supplied as:
- 1 × 1ml prefilled syringe
The product presentation is designed for professional aesthetic use and should be stored and handled according to manufacturer requirements.
Longevity
As a polynucleotide-based injectable, Rejuran S is designed to support gradual improvement in skin quality through biological mechanisms rather than providing immediate volume augmentation like traditional dermal fillers.
The duration of visible effects can vary depending on:
- individual patient characteristics,
- treatment area,
- practitioner protocol,
- biological response.
A specific manufacturer-confirmed longevity period for Rejuran S was not identified in publicly available product documentation.




