Description
Restylane® Defyne with Lidocaine Dermal Filler 1 × 1 mL
Restylane® Defyne with Lidocaine is an injectable hyaluronic acid (HA) dermal filler medical device developed by Galderma for the correction of moderate to severe facial wrinkles and folds and for facial contour enhancement. Formulated using XpresHAn Technology™, Restylane Defyne is designed to provide structured support while maintaining flexibility in dynamic facial areas. The addition of lidocaine improves patient comfort during injection.
The gel is intended for deep dermal to subcutaneous placement, delivering lift and projection while adapting to natural facial expressions. Within the Restylane portfolio, Restylane Defyne filler is positioned for areas requiring stronger structural support compared with softer formulations.
What Restylane® Defyne Is Similar To
Restylane Defyne can be regarded alongside other high-support hyaluronic acid dermal fillers designed for deeper facial folds and contour correction. Within the Restylane range, it is commonly compared with Restylane Refyne.
In the context of flexibility and support, Refyne is typically used for milder lines, whereas restylane defyne with lidocaine offers firmer structural support for more pronounced folds. Clinically, restylane defyne cheeks treatments may focus on contour restoration, while use in lips is more selective. This comparison is provided for clinical orientation only and does not imply interchangeability.
Treatment Areas / Indications
According to manufacturer documentation, Restylane Defyne with Lidocaine is indicated for correction of moderate to severe facial wrinkles and folds and for facial contour restoration.
Treatment areas may include:
Nasolabial folds • Marionette lines • Chin • Jawline • Cheeks • Lips (for structural enhancement where clinically appropriate)
Usage / Administration (IFU-only)
Injection depth: Deep dermal to subcutaneous layer.
Volume per point / injection site: Not provided by manufacturer.
Needle gauge: Supplied with sterile needles as per packaging.
Frequency / number of sessions: Not provided by manufacturer.
Professional-use disclaimer: Administered only by qualified medical professionals under aseptic conditions.
If any parameter is omitted in the official IFU, it is marked as “not provided by manufacturer.”
Ingredient List
Cross-linked hyaluronic acid (non-animal origin)
Lidocaine hydrochloride
Physiological buffer solution
Other excipients as per IFU; additional trace components not disclosed.
Presentation & Longevity
Presentation: 1 × 1 mL pre-filled sterile syringe
Shelf-life: Not specified in public documentation; refer to packaging for expiry date.
Longevity (treatment duration): Results are typically reported to last approximately 12 months or longer, depending on treatment area, injection technique, and individual patient metabolism.
Safety Notes / Contraindications
Use is contraindicated in patients with known hypersensitivity to hyaluronic acid, lidocaine, or any component of the product.
Avoid use in patients with active infection, inflammation, or compromised skin at the injection site until resolved.
Do not inject intravascularly.
Single use only; do not reuse the syringe; ensure packaging is intact and within expiry.
Regulatory Status
CE-marked medical device in Europe.
UKCA status: verify via IFU or authorised distributor.
Regulatory classification may vary by jurisdiction; verify on the product packaging or manufacturer’s IFU.
FAQ
1. What is Restylane® Defyne?
Restylane Defyne is a hyaluronic acid dermal filler designed for correction of moderate to severe facial wrinkles and for contour enhancement.
2. How is Restylane Defyne different from Refyne?
Restylane Defyne provides stronger structural support and is typically used for deeper folds, whereas Refyne offers softer correction for moderate lines.
3. Can Restylane Defyne be used in the cheeks?
Yes. Restylane Defyne cheeks treatments may focus on restoring contour and providing structural lift in the midface.
4. Is Restylane Defyne suitable for lips?
Restylane Defyne lips treatments may be performed when stronger definition or projection is required, though softer lip-specific fillers are often preferred for delicate shaping.
5. How long do Restylane Defyne results last?
Results are commonly reported to last around 12 months or longer, depending on patient factors and treated areas.
