Description
Restylane® Refyne with Lidocaine Dermal Filler 1 × 1 mL
Restylane® Refyne with Lidocaine is an injectable hyaluronic acid (HA) dermal filler medical device developed by Galderma for the correction of mild to moderate facial wrinkles and folds, particularly in dynamic areas of the face. Formulated using XpresHAn Technology™, Restylane Refyne is designed to provide flexible support that adapts to facial movement while maintaining natural-looking results. The inclusion of lidocaine enhances patient comfort during treatment.
The gel is intended for mid-dermal to deep dermal placement, allowing smooth tissue integration and support without rigidity. Within the Restylane portfolio, Restylane Refyne is positioned for subtle refinement and soft correction rather than high-volume structural augmentation.
What Restylane® Refyne Is Similar To
Restylane Refyne can be regarded alongside other flexible hyaluronic acid dermal fillers designed for areas of frequent facial movement, such as nasolabial folds and marionette lines. Within the Restylane range, it is commonly compared with Restylane Defyne.
In the context of Restylane Refyne vs Defyne, Refyne is generally positioned for milder to moderate correction, offering softer support and greater flexibility, while Defyne is formulated for deeper folds requiring stronger projection. Restylane Refyne may also be considered for Restylane Refyne lips in selected cases where subtle enhancement and movement preservation are desired. This comparison is provided for clinical orientation only and does not imply interchangeability.
Treatment Areas / Indications
According to manufacturer documentation, Restylane Refyne with Lidocaine is indicated for correction of mild to moderate facial wrinkles and folds.
Treatment areas may include:
Nasolabial folds • Marionette lines • Perioral lines • Lips (for subtle enhancement where clinically appropriate)
Usage / Administration (IFU-only)
Injection depth: Mid-dermal to deep dermal layer.
Volume per point / injection site: Not provided by manufacturer.
Needle gauge: Supplied with sterile needles as per packaging.
Frequency / number of sessions: Not provided by manufacturer.
Professional-use disclaimer: Administered only by qualified medical professionals under aseptic conditions.
If any parameter is omitted in the official IFU, it is marked as “not provided by manufacturer.”
Ingredient List
Cross-linked hyaluronic acid (non-animal origin)
Lidocaine hydrochloride
Physiological buffer solution
Other excipients as per IFU; additional trace components not disclosed.
Presentation & Longevity
Presentation: 1 × 1 mL pre-filled sterile syringe
Shelf-life: Not specified in public documentation; refer to packaging for expiry date.
Longevity (treatment duration): Results are typically reported to last approximately 9–12 months, depending on treatment area, injection technique, and individual patient metabolism.
→ Restylane Refyne price may vary by distributor and region.
Safety Notes / Contraindications
Use is contraindicated in patients with known hypersensitivity to hyaluronic acid, lidocaine, or any component of the product.
Avoid use in patients with active skin infection, inflammation, or lesions at the injection site until resolved.
Do not inject intravascularly.
Single use only; do not reuse the syringe; ensure packaging is intact and within expiry.
Regulatory Status
CE-marked medical device in Europe.
UKCA status: verify via IFU or authorised distributor.
Regulatory classification may vary by jurisdiction; verify on the product packaging or manufacturer’s IFU.
FAQ
1. What is Restylane® Refyne?
Restylane Refyne is a hyaluronic acid dermal filler designed for correction of mild to moderate wrinkles while preserving natural facial movement.
2. What is the difference between Restylane Refyne vs Defyne?
Restylane Refyne provides softer, more flexible correction for moderate lines, while Defyne offers stronger structural support for deeper folds.
3. Can Restylane Refyne be used in the lips?
Yes. Restylane Refyne in the lips may be used for subtle enhancement or refinement where flexibility and natural expression are priorities.
4. How long do Restylane Refyne results last?
Results are commonly reported to last between 9 and 12 months, depending on patient factors and treated area.
5. Does Restylane Refyne contain lidocaine?
Yes. Restylane Refyne with lidocain (lidocaine) includes an integrated anaesthetic component to improve comfort during injection.
